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Five people were hospitalized after a three-car crash Wednesday in Upper Marlboro, and state police now are trying to determine why a driver was traveling north in the southbound lanes of Route 4.

Three drivers and two passengers were taken to Prince George’s Hospital Center in Cheverly for injuries that were serious but not life-threatening after the collision occurred around 5:45 a.m.

Cpl. Charles Harvey, a Maryland State Police spokesman, said the driver of a Jeep was traveling north in the southbound lanes of Route 4 when the Jeep struck a box truck. The Jeep’s driver was among the five injured, police said.

“It clipped it. And after clipping the box truck, it struck a GMC behind the box truck,” Harvey said.

He said the front-seat passenger in the GMC truck was flown to the hospital by helicopter while the three drivers and a passenger in the box truck were transported by ambulance.

Harvey said officers went to Prince George’s Hospital Center to interview the drivers and passengers and determine a cause for the collision.

Harvey said the section of Route 4 at U.S. 301 remained closed until around 7:45 a.m.